Glycosylated ovine prolactin.
نویسندگان
چکیده
منابع مشابه
Conformational similarity of ovine prolactin and bovine growth hormone.
The behavior and properties of ovine prolactin have been evaluated by measurements of fluorescence, polarization of fluorescence, absorption, optical rotation, and circular dichroism. The helical content of the native molecule at pH 8 is 60 per cent as determined by circular dichroism. Three molecular transitions have been followed. The one in acid affects only 20 per cent of the helical residu...
متن کاملImmunobiological actions of antiserum to ovine prolactin in mice.
Neutralization of pituitary prolactin by the administration of antiserum to prolactin in the mouse selectively blocked the pro-oestrous stage of the oestrous cycle and inhibited ovulation in normal cyclic mice. In pseudopregnant mice, the antiserum shortened the duration of pseudopregnancy. Failure of the antiserum to affect uterine cell division, blastocyst implantation and pregnancy suggests ...
متن کاملExpression of the extracellular domain of the rat liver prolactin receptor and its interaction with ovine prolactin.
A clone of the extracellular domain of the rat liver prolactin receptor was generated by the RNA-based polymerase chain reaction, and the NH2-terminal 210 amino acids were expressed in HeLa cells using a vaccinia virus/T7 hybrid expression system. The protein was isolated from serum-free culture medium directly by chromatography on an ovine prolactin affinity column and yielded approximately 1....
متن کاملRegulation of prolactin receptor expression in ovine skin in relation to circulating prolactin and wool follicle growth status.
Seasonal patterns of hair growth are governed, at least in part, by levels of prolactin in circulation, and although receptors for prolactin (PRLR) have been demonstrated in hair follicles, little is known of their regulation in relation to follicular cycles. In this study, a photoperiod-generated increase in prolactin was used to induce a wool follicle cycle during which changes in PRLR expres...
متن کاملProlactin messenger ribonucleic acid concentrations throughout the ovine estrous cycle: assessment relative to prolactin serum and pituitary amounts.
Prolactin (PRL) mRNA concentrations were assessed by nucleic acid hybridization assays in pituitaries of ewes representing the defined stages of the ovine estrous cycle. Concomitantly, pituitary and serum PRL concentrations were measured in these ewes using radioimmunoassays. It was observed that PRL serum, pituitary and mRNA concentrations tended to increase near the time of the gonadotropin p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1984
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.81.2.385